"I am excited that once this tour is over, I'll be announcing a new direction for War of the Worlds," says Wayne.
"It's something that I have never done before and gives it a life thereafter. It's the right time to put my energies into it.
"All I can say at the moment is that it will have lots of new ingredients. It's not the end of the War of the Worlds if what we do next succeeds."
The science fiction story about Earth being invaded by Martians was written by HG Wells in 1897 as a serialised adventure for Pearson's Magazine in the UK and the US's Cosmopolitan magazine. It proved so popular that a publisher asked the author to "glue" the episodes together and issue it as a book.
Jeff Wayne adapted the story into a musical version in the 1970s and has never looked back.
Wayne said: "Although it was a dark, Victorian tale, I've had many people say to me that they can relate to it because of the descriptions in the book. This story has resonated with every generation because it's an invasion story.
Every generation has those issues, whether it's one nation fighting another or a superstate in charge of a nation. Even with the Roman story of Sparticus, it's about the masters ruling over the slaves like an alien force.