High rollers, who made a million-pound buy-in to play in the game, will gather at the Park Lane venue from August 1 to 3 for the flagship event in the Triton Poker High Roller Series.
It raises money for seven charities: Malaysian Red Crescent, Sarawak Children's Cancer Society, One Drop, Credit One World Charity Foundation, Healthy Hong Kong, REG and Caring for Children Foundation Macau.
Visitors to the Hilton will see both professional and recreational players that include Triton ambassadors Tom Dwan and Jason Koon, David Peters, Rui Cao, and Bryn Kenney.
Between them, these five alone have combined poker winnings of more than £100 million.
Some of the most famous poker players in the world are involved
The series has a unique 'invitation-only' formula to play and the only way to secure participation is either to be invited directly by Triton Poker or the be an invitation holder's nominated guest.
Poker fans will be able to get involved as it will be live-streamed online so viewers can feel as though they are in the room for the August 1 charity game.
While the full Triton Super High Roller Series in London runs from July 31 to August 8 featuring at least eight distinct high buy-in tournaments.
Each £1,000,000 buy-in comes with an additional £50,000 entry fee, the entirety of which will go directly to charity, assuring several million pounds for a variety of worthwhile causes.
Whoever emerges as the champion could earn more in a single tournament than has ever been won at any event anywhere in the world.
Among the recreational players who have already accepted an invitation to play are Hong Kong investor Stanley Choi, Dusk Til Dawn founder Rob Yong, 1978 WSOP Main Event champion Bobby Baldwin, Richard Yong from Malaysia and American entrepreneur Rick Salomon along with Triton Co-Founder Paul Phua.
Jason Koon, who lies eighth on the world's all-time poker money list, has nearly $29 million in live tournament winnings, said: "I love to play big stakes against tough competition, and no one checks those boxes quite like Triton.
"There has never been a poker tournament with a buy-in of this size before, all the players will be part of poker history.
"London is one of the most historically rich, beautiful cities in the world so it's very fitting that this history-making event will be taking place here in the heart of the city."
American Bryn Kenney, who won the last Triton Poker Super High Roller Series Main Event in Montenegro in May, has more than $34 million in live poker winnings to his name and is ranked fourth in the world.
While David Peters, ranked fifth in the world, has winnings of more than $33 million including Triton Poker Super High Roller Series victory from Jeju.
The live stream will run throughout the £1,000,000 buy-in charity event and can be viewed on the Triton website, Twitch, YouTube and Facebook as well as several Chinese TV channels.