Retelling the famous "divorced- beheaded - died - divorced - beheaded - survived" story from history, the musical is described as a 75-minute "celebration of 21st Century girl power" with the characters even having an all-female band, The Ladies in Waiting.
The show first appeared at the Edinburgh Festival Fringe in 2018 and opened in the West End in January this year. It's proved so popular that songs from the musical have received more than 2 million weekly streams and gone into the charts.
The Six UK tour comes as the show also heads around the world to stages as far as Australia and America.
Chris Sudworth, Director of Artistic Programme at Birmingham Hippodrome said: "We are incredibly excited to be bringing this hit home-grown British musical to Birmingham for the very first time."
He added: "From seeing the show during its very beginnings at the Edinburgh Festival, I have watched this production grow and grow in popularity, gaining rave reviews and sell-out standing ovations and now we can't wait for our audiences to experience this very special show."
Six is a homegrown musical that debuted at the Edinburgh Fringe